Effects+on+the+brain

= Marijuana's Effects on the Brain =

THC and other cannabinoids are known to bind to two receptors, designated CB1 and CB2. There are substantial differences in the structures of these two receptors and their anatomical distribution in the body. CB2 receptors are found mainly outside the brain in immune cells, suggesting that cannabinoids may play a role in the modulation of the immune response. CB1 receptors are found throughout the body, but primarily in the brain. These receptors are much more abundant then receptors for morphine and heroin, suggesting that the potential actions of cannabinoids are widespread. The locations of CB1 receptors in the brain also may provide some clues about their functions. For example, the highest density of CB1 receptors has been found in cells of the basal ganglia; its primary components include the caudate nucleus, putamen, and globus pallidus. Cells of the basal ganglia are involved in coordinating body movements. Other regions that also contain a larger number of CB1 receptors include the cerebellum, which coordinates fine body movements; the hippocampus, which is involved in aspects of memory storage; the cerebral cortex, which regulates integration of higher cognitive functions; and the nucleus accumbens, which is involved in reward.